ONE-FLOW Research collaboration project enabled an asymmetric organocatalytic aldol reaction in flow


Jointly with Professor Dr. Volker Hessel from Einhoven University of Technology (now: University of Adelaide) and Professor Dr. Albrecht Berkessel from University of Cologne the team around Professor Dr. Harald Gröger at Bielefeld University have published their results within the EU-Project ONE-FLOW on an “Asymmetric Organocatalytic Aldol Reaction of a Hydrophobic Aldehyde in Aqueous Medium Running in Flow Mode” in the journal SYNTHESIS. The paper will be published as part of the 50 Years SYNTHESIS – Golden Anniversary Issue and is available as an open access article (DOI: 10.1055/s-0037-1610404). This successful asymmetric organocatalytic flow process addresses the research vision towards efficient chemoenzymatic cascades for the continuous production of pharmaceuticals.

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