Results and publications

2021 Scientific publications

39. C. Méhault, L. Vanoye, R. Philippe, C. de Bellefon, Multiphase alternated slug flows: conditions to avoid coalescence and characterization of mass transfer between droplets Chem Eng. J., 2021, 407, 127215

38. A.M. Bago Rodriguez, L. Schober, A. Hinzmann, H. Gröger and B.P. Binks Effect of Particle Wettability and Particle Concentration on the Enzymatic Dehydration of n-Octanaloxime in Pickering emulsions, Angew. Chem. Int. Ed. 2021, 60, 1450–1457.

37. Victor R. L. J. Bloemendal, Bram Spierenburg, Thomas J. Boltje, Jan C. M. van Hest & Floris P. J. T. Rutjes, One-flow synthesis of tetrahydrocannabinol and cannabidiol using homo- and heterogeneous Lewis acids, in J Flow Chem

2020 Scientific publications

36. S. V. Ley, Y. Chen, D. E. Fitzpatrick and O. S. May Living with our machines: Towards a more sustainable future Current Opinion in Green and Sustainable Chemistry 2020, 25, 100353

35. Y. Chen, N. McNamara, O. May, T. Pillaiyar, D. C. Blakemore, and S. V. Ley, Photoredox Generation of Sulfonyl Radicals and Coupling with Electron Deficient Olefins  Org. Lett. 2020, 22, 5746–5748. 

34. D.E. Fitzpatrick A tutored discourse on microcontrollers, single board computers and their applications to monitor and control chemical reactions 2020 Reaction Chemistry & Engineering 10.1039/C9RE00407F

33. E. Watanabe, Y. Chen, O. May, and S. V. Ley, A Practical Method for Continuous Production of sp3‐Rich Compounds from (Hetero)Aryl Halides and Redox‐Active Esters Chem. Eur. J. 2020, 26, 186-191

32. Fabio Tonin, Elisabet Martì, Isabel W. C. E. Arends and Ulf Hanefeld, Laccase Did It Again: A Scalable and Clean Regeneration System for NAD+ and Its Application in the Synthesis of 12-oxo-Hydroxysteroids, in Catalysts, 2020, 10 (6), 677

31. Bloemendal V.R.L.J., Janssen M.A.C.H., van Hest J.C.M., Rutjes F.P.J.T., Continuous one-flow multi-step synthesis of active pharmaceutical ingredients in React. Chem. Eng., 2020, 5, 1186-1197

30. Bloemendal V.R.L.J., van Hest J.C.M., Rutjes F.P.J.T., Synthetic Pathways to Tetrahydrocannabinol (THC): An Overview in Org. Biomol. Chem., 2020, 18, 3203-3215


29. Zhang C., Song Z., Jin C., Nijhuis J., Zhous T., Noel T., Groger H., Sundmacher K., van Hest J.C.M., Hessel V., Screening of functional solvent system for automatic aldehyde and ketone separation in aldol reaction: A combined COSMO-RS and experimental approach, in Chemical Engineering Journal, 2020


28. De Martino T.M., Tonin F., Yewdall A.N., Abdelghani M., Williams D.S., Hanefeld U., Rutjes F.P.J.T., Abdelmohsen L.K.E.A., Hest J.C.M, Compartmentalized cross-linked enzymatic nano-aggregates (c-CLEnA) for efficient in-flow biocatalysis, in Chemical Science, 2020

 27. Hiebler, K., Dertnig, C., Soritz, S. et al. Development of a multistep reaction cascade for the synthesis of a sacubitril precursor in continuous flow in J Flow Chem, 2020, 10, 259–270

26. K. Hiebler , S. Soritz , K. Gavric,  S. Birrer, M. C. Maier , B. Grabner , H. Gruber-Woelfler. Multistep synthesis of a valsartan precursor in continuous flow. in Journal of Flow Chemistry 2020, 10, 283–294


2019 Scientific publications

25. A. M. Bago Rodriguez, B. P. Binks Capsules from Pickering emulsion templates Current Opinion in Colloid & Interface Science 2019, 44, 107-129

24. S. Yu, D. Zhang, J. Jiang, Z. Cui, W. Xia, B. Binks, H. Yang Biphasic Biocatalysis using a CO2-Switchable Pickering Emulsion Green Chem., 2019

23. Y. Chen, M. Leonardi, P. Dingwall, R. Labes, D.C. Blakemore, P. Pasau and S.V. Ley Photochemical homologation for the preparation of aliphatic aldehyde in flow, J. Org. Chem., 2018, 83, 15558-15568

22. X. Yang, Y. Wang, R. Bai, H. Ma, W. Wang, H. Sun, Y. Dong, F. Qu, Q. Tang, T. Guo, B.P. Binks and T. Meng Pickering emulsion-enhanced interfacial biocatalysis: Tailored alginate microparticles act as particulate emulsifier and enzyme carrier. Green Chem., 2019, 10.1039/c8gc03573c

21. Y. Chen, O. May, D. C. Blakemore, and S. V. Ley A Photoredox Coupling Reaction of Benzylboronic Esters and Carbonyl Compounds in Batch and Flow Org. Lett. 2019, 21, 6140−6144

20. O. M. Morales Gonzalez, M. Escribà Gelonch, V. Hessel Life cycle assessment of vitamin D3 synthesis: from batch to photo-high, 2019 Int. J. Life Cycle Assess,24, 2111-2127

19. S. V. Ley, Y. Chen, D.E. Fitzpatrick, and O. May, A New World for Chemical Synthesis? CHIMIA 2019, 73, 792-802.

18. O. M. Morales Gonzalez, C. Zhang, S. Li, et al. Solvent impact assessment for the “One-Flow Functional Solvent Factory Chem. Eng. Sci.: X, 2019, 3: 100024.

17. C. Zhang, Z. Song, C. Jin, J. Nijhuis, T. Zhou, T. Noel, H. Gröger, K. Sundmacher, J.C.M. van Hest, V. Hessel Screening of functional solvent system for automatic aldehyde and ketone separation in aldol reaction: A combined COSMO-RS and experimental approach Chem Eng J., 2019: 123399

16. S.Yu, D. Zhang , J. Jiang, Z. Cui, W. Xia, B. P. Binks and H. Yang Biphasic biocatalysis using a CO2-switchable Pickering emulsion in Green Chem. 2019, 21, 4062-4068

15. Tonin, F., Alvarenga, N., Ye, J. Z., Arends, I. W., & Hanefeld, U. (2019). Clean Enzymatic Oxidation of 12α‐Hydroxysteroids to 12‐Oxo‐Derivatives Catalyzed by Hydroxysteroid Dehydrogenase in Advanced Synthesis & Catalysis, 2019(361), 2448-2455

14. Tonin, F., Otten, L. G., & Arends, I. W. (2018). NAD+‐Dependent Enzymatic Route for the Epimerization of Hydroxysteroids. ChemSusChem. 2018(11), 1-13

13. Schober, L., Ratnam, S., Yamashita, Y., Adebar, N., Pieper, M., Berkessel, A., Hessel, V. & Gröger, H. (2019). An asymmetric organocatalytic aldol reaction of a hydrophobic aldehyde in aqueous medium running in flow mode. Synthesis, 51(05), 1178-1184.

12. Bloemendal, V. R., Sondag, D., Elferink, H., Boltje, T. J., van Hest, J. C., & Rutjes, F. P. (2019). A Revised Modular Approach to (–)‐trans‐Δ8‐THC and Derivatives Through Late‐Stage Suzuki–Miyaura Cross‐Coupling Reactions. European Journal of Organic Chemistry, 2019(12), 2289-2296.

11. Bloemendal, V. R., Moons, S. J., Heming, J. J., Chayoua, M., Niesink, O., van Hest, J. C., Hest & Rutjes, F. P. (2019). Chemoenzymatic Synthesis of Sialic Acid Derivatives Using Immobilized N‐Acetylneuraminate Lyase in a Continuous Flow Reactor. Advanced Synthesis & Catalysis, 2019(361), 2443-2447

2018 Scientific publications

10. D. J. Ritson, C. Battilocchio, S.V. Ley and J. D. Sutherland Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry Nature Communications 2018, 9, 1821

9. Y. Chen, D.C. Blakemore, P. Pasau and S.V. Ley  Three-Component Assembly of Multiply Substituted Homoallylic Alcohols and Amines Using a Flow Chemistry PhotoreactorOrg. Lett. 2018,  20, 6569-6572

8. P. Dingwall, A. Greb, L. N. S. Crespin, R. Labes, B. Musio, J.S. Poh, P. Pasau, D. C. Blakemore and S. V. Ley  C–H functionalisation of aldehydes using light generated, non-stabilised diazo compounds in flow, Chem. Comm. 2018, 54, 11685 – 11688

7. De Martino, M. T., Abdelmohsen, L. K., Rutjes, F. P., & van Hest, J. C. (2018). Nanoreactors for green catalysis. Beilstein journal of organic chemistry, 14(1), 716-733.

6. Hiebler, K., Lichtenegger, G. J., Maier, M. C., Park, E. S., Gonzales-Groom, R., Binks, B. P., & Gruber-Woelfler, H. (2018). Heterogeneous Pd catalysts as emulsifiers in Pickering emulsions for integrated multistep synthesis in flow chemistry. Beilstein journal of organic chemistry, 14(1), 648-658.

5. Tonin, F., & Arends, I. W. (2018). Latest development in the synthesis of ursodeoxycholic acid (UDCA): a critical review. Beilstein journal of organic chemistry, 14(1), 470-483.

4. D.E. Fitzpatrick, S.V. Ley Engineering chemistry for the future of chemical synthesis Tetrahedron 2018, 74, 3087-3100

3. Fitzpatrick, D. E., Maujean, T., Evans, A. C., & Ley, S. V. (2018). Across‐the‐World Automated Optimization and Continuous‐Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud‐Based Server. Angewandte Chemie, 130(46), 15348-15352. 

2. Fitzpatrick, D. E., Mutton, R. J., & Ley, S. V. (2018). In-line separation of multicomponent reaction mixtures using a new semi-continuous supercritical fluid chromatography system. Reaction Chemistry & Engineering, 3(5), 799-806.

2017 Scientific publications

1. A. Greb, J-S. Poh, S. Greed, C. Battilocchio, P. Pasau, D. C. Blakemore and S. V. Ley A Versatile Route to Unstable Diazo Compounds via Oxadiazolines and their Use in Aryl–Alkyl Cross-Coupling Reactions  Angew. Chem. Int. Ed. 2017, 56, 16602 –16605.