Scientific publications

Hiebler, K., Dertnig, C., Soritz, S. et al. Development of a multistep reaction cascade for the synthesis of a sacubitril precursor in continuous flow in  J Flow Chem (2019)



S.Yu, D. Zhang , J. Jiang, Z. Cui, W. Xia, B. P. Binks and H. Yang Biphasic biocatalysis using a CO2-switchable Pickering emulsion in Green Chem. , 2019,21, 4062-4068


K. Hiebler , S. Soritz , K. Gavric,  S. Birrer, M. C. Maier , B. Grabner , H. Gruber-Woelfler. Multistep synthesis of a valsartan precursor in continuous flow. Journal of Flow Chemistry (2019).



Tonin, F., Alvarenga, N., Ye, J. Z., Arends, I. W., & Hanefeld, U. (2019). Clean Enzymatic Oxidation of 12α‐Hydroxysteroids to 12‐Oxo‐Derivatives Catalyzed by Hydroxysteroid Dehydrogenase in Advanced Synthesis & Catalysis, 2019(361), 2448-2455

Tonin, F., Otten, L. G., & Arends, I. W. (2018). NAD+‐Dependent Enzymatic Route for the Epimerization of Hydroxysteroids. ChemSusChem. 2018(11), 1-13

Schober, L., Ratnam, S., Yamashita, Y., Adebar, N., Pieper, M., Berkessel, A., Hessel, V. & Gröger, H. (2019). An asymmetric organocatalytic aldol reaction of a hydrophobic aldehyde in aqueous medium running in flow mode. Synthesis, 51(05), 1178-1184.

Bloemendal, V. R., Sondag, D., Elferink, H., Boltje, T. J., van Hest, J. C., & Rutjes, F. P. (2019). A Revised Modular Approach to (–)‐trans‐Δ8‐THC and Derivatives Through Late‐Stage Suzuki–Miyaura Cross‐Coupling Reactions. European Journal of Organic Chemistry, 2019(12), 2289-2296.

Bloemendal, V. R., Moons, S. J., Heming, J. J., Chayoua, M., Niesink, O., van Hest, J. C., Hest & Rutjes, F. P. (2019). Chemoenzymatic Synthesis of Sialic Acid Derivatives Using Immobilized N‐Acetylneuraminate Lyase in a Continuous Flow Reactor. Advanced Synthesis & Catalysis, 2019(361), 2443-2447


Scientific publications

De Martino, M. T., Abdelmohsen, L. K., Rutjes, F. P., & van Hest, J. C. (2018). Nanoreactors for green catalysis. Beilstein journal of organic chemistry, 14(1), 716-733.

Hiebler, K., Lichtenegger, G. J., Maier, M. C., Park, E. S., Gonzales-Groom, R., Binks, B. P., & Gruber-Woelfler, H. (2018). Heterogeneous Pd catalysts as emulsifiers in Pickering emulsions for integrated multistep synthesis in flow chemistry. Beilstein journal of organic chemistry, 14(1), 648-658.

Tonin, F., & Arends, I. W. (2018). Latest development in the synthesis of ursodeoxycholic acid (UDCA): a critical review. Beilstein journal of organic chemistry, 14(1), 470-483.

Fitzpatrick, D. E., Maujean, T., Evans, A. C., & Ley, S. V. (2018). Across‐the‐World Automated Optimization and Continuous‐Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud‐Based Server. Angewandte Chemie, 130(46), 15348-15352.

Fitzpatrick, D. E., Mutton, R. J., & Ley, S. V. (2018). In-line separation of multicomponent reaction mixtures using a new semi-continuous supercritical fluid chromatography system. Reaction Chemistry & Engineering, 3(5), 799-806.