Results
2020
Scientific publications
Fabio Tonin, Elisabet Martì, Isabel W. C. E. Arends and Ulf Hanefeld, Laccase Did It Again: A Scalable and Clean Regeneration System for NAD+ and Its Application in the Synthesis of 12-oxo-Hydroxysteroids, in Catalysts, 2020, 10 (6), 677
Bloemendal V.R.L.J., Janssen M.A.C.H., van Hest J.C.M., Rutjes F.P.J.T., Continuous one-flow multi-step synthesis of active pharmaceutical ingredients in React. Chem. Eng., 2020, 5, 1186-1197
Bloemendal V.R.L.J., van Hest J.C.M., Rutjes F.P.J.T., Synthetic Pathways to Tetrahydrocannabinol (THC): An Overview in Org. Biomol. Chem., 2020, 18, 3203-3215
Zhang C., Song Z., Jin C., Nijhuis J., Zhous T., Noel T., Groger H., Sundmacher K., van Hest J.C.M., Hessel V., Screening of functional solvent system for automatic aldehyde and ketone separation in aldol reaction: A combined COSMO-RS and experimental approach, in Chemical Engineering Journal, 2020
De Martino T.M., Tonin F., Yewdall A.N., Abdelghani M., Williams D.S., Hanefeld U., Rutjes F.P.J.T., Abdelmohsen L.K.E.A., Hest J.C.M, Compartmentalized cross-linked enzymatic nano-aggregates (c-CLEnA) for efficient in-flow biocatalysis, in Chemical Science, 2020
Hiebler, K., Dertnig, C., Soritz, S. et al. Development of a multistep reaction cascade for the synthesis of a sacubitril precursor in continuous flow in J Flow Chem, 2020, 10, 259–270
K. Hiebler , S. Soritz , K. Gavric, S. Birrer, M. C. Maier , B. Grabner , H. Gruber-Woelfler. Multistep synthesis of a valsartan precursor in continuous flow. in Journal of Flow Chemistry 2020, 10, 283–294
2019
Scientific publications
S.Yu, D. Zhang , J. Jiang, Z. Cui, W. Xia, B. P. Binks and H. Yang Biphasic biocatalysis using a CO2-switchable Pickering emulsion in Green Chem. 2019, 21, 4062-4068
Tonin, F., Alvarenga, N., Ye, J. Z., Arends, I. W., & Hanefeld, U. (2019). Clean Enzymatic Oxidation of 12α‐Hydroxysteroids to 12‐Oxo‐Derivatives Catalyzed by Hydroxysteroid Dehydrogenase in Advanced Synthesis & Catalysis, 2019(361), 2448-2455
Tonin, F., Otten, L. G., & Arends, I. W. (2018). NAD+‐Dependent Enzymatic Route for the Epimerization of Hydroxysteroids. ChemSusChem. 2018(11), 1-13
Schober, L., Ratnam, S., Yamashita, Y., Adebar, N., Pieper, M., Berkessel, A., Hessel, V. & Gröger, H. (2019). An asymmetric organocatalytic aldol reaction of a hydrophobic aldehyde in aqueous medium running in flow mode. Synthesis, 51(05), 1178-1184.
Bloemendal, V. R., Sondag, D., Elferink, H., Boltje, T. J., van Hest, J. C., & Rutjes, F. P. (2019). A Revised Modular Approach to (–)‐trans‐Δ8‐THC and Derivatives Through Late‐Stage Suzuki–Miyaura Cross‐Coupling Reactions. European Journal of Organic Chemistry, 2019(12), 2289-2296.
Bloemendal, V. R., Moons, S. J., Heming, J. J., Chayoua, M., Niesink, O., van Hest, J. C., Hest & Rutjes, F. P. (2019). Chemoenzymatic Synthesis of Sialic Acid Derivatives Using Immobilized N‐Acetylneuraminate Lyase in a Continuous Flow Reactor. Advanced Synthesis & Catalysis, 2019(361), 2443-2447
2018
Scientific publications
De Martino, M. T., Abdelmohsen, L. K., Rutjes, F. P., & van Hest, J. C. (2018). Nanoreactors for green catalysis. Beilstein journal of organic chemistry, 14(1), 716-733.
Hiebler, K., Lichtenegger, G. J., Maier, M. C., Park, E. S., Gonzales-Groom, R., Binks, B. P., & Gruber-Woelfler, H. (2018). Heterogeneous Pd catalysts as emulsifiers in Pickering emulsions for integrated multistep synthesis in flow chemistry. Beilstein journal of organic chemistry, 14(1), 648-658.
Tonin, F., & Arends, I. W. (2018). Latest development in the synthesis of ursodeoxycholic acid (UDCA): a critical review. Beilstein journal of organic chemistry, 14(1), 470-483.
Fitzpatrick, D. E., Maujean, T., Evans, A. C., & Ley, S. V. (2018). Across‐the‐World Automated Optimization and Continuous‐Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud‐Based Server. Angewandte Chemie, 130(46), 15348-15352.
Fitzpatrick, D. E., Mutton, R. J., & Ley, S. V. (2018). In-line separation of multicomponent reaction mixtures using a new semi-continuous supercritical fluid chromatography system. Reaction Chemistry & Engineering, 3(5), 799-806.
- 15-06-2020
- One Flow online progress meeting
- 30-04-2020
- (Digital) ONE-FLOW meeting on June 12
- 20-03-2020
- Next ONE-FLOW meeting is postponed