Scientific publications

Bloemendal V.R.L.J., Janssen M.A.C.H., van Hest J.C.M., Rutjes F.P.J.T., Continuous one-flow multi-step synthesis of active pharmaceutical ingredients in React. Chem. Eng., (2020), Accepted manuscript


Bloemendal V.R.L.J., van Hest J.C.M., Rutjes F.P.J.T., Synthetic Pathways to Tetrahydrocannabinol (THC): An Overview in Org. Biomol. Chem., (2020), 18, 3203-3215


Zhang C., Song Z., Jin C., Nijhuis J., Zhous T., Noel T., Groger H., Sundmacher K., van Hest J.C.M., Hessel V., Screening of functional solvent system for automatic aldehyde and ketone separation in aldol reaction: A combined COSMO-RS and experimental approach, in Chemical Engineering Journal (2020)


 De Martino T.M., Tonin F., Yewdall A.N., Abdelghani M., Williams D.S., Hanefeld U., Rutjes F.P.J.T., Abdelmohsen L.K.E.A., Hest J.C.M, Compartmentalized cross-linked enzymatic nano-aggregates (c-CLEnA) for efficient in-flow biocatalysis, in Chemical Science (2020)

 Hiebler, K., Dertnig, C., Soritz, S. et al. Development of a multistep reaction cascade for the synthesis of a sacubitril precursor in continuous flow in  J Flow Chem (2020)


Scientific publications

S.Yu, D. Zhang , J. Jiang, Z. Cui, W. Xia, B. P. Binks and H. Yang Biphasic biocatalysis using a CO2-switchable Pickering emulsion in Green Chem. , 2019, 21, 4062-4068


K. Hiebler , S. Soritz , K. Gavric,  S. Birrer, M. C. Maier , B. Grabner , H. Gruber-Woelfler. Multistep synthesis of a valsartan precursor in continuous flow. Journal of Flow Chemistry (2019).



Tonin, F., Alvarenga, N., Ye, J. Z., Arends, I. W., & Hanefeld, U. (2019). Clean Enzymatic Oxidation of 12α‐Hydroxysteroids to 12‐Oxo‐Derivatives Catalyzed by Hydroxysteroid Dehydrogenase in Advanced Synthesis & Catalysis, 2019(361), 2448-2455

Tonin, F., Otten, L. G., & Arends, I. W. (2018). NAD+‐Dependent Enzymatic Route for the Epimerization of Hydroxysteroids. ChemSusChem. 2018(11), 1-13

Schober, L., Ratnam, S., Yamashita, Y., Adebar, N., Pieper, M., Berkessel, A., Hessel, V. & Gröger, H. (2019). An asymmetric organocatalytic aldol reaction of a hydrophobic aldehyde in aqueous medium running in flow mode. Synthesis, 51(05), 1178-1184.

Bloemendal, V. R., Sondag, D., Elferink, H., Boltje, T. J., van Hest, J. C., & Rutjes, F. P. (2019). A Revised Modular Approach to (–)‐trans‐Δ8‐THC and Derivatives Through Late‐Stage Suzuki–Miyaura Cross‐Coupling Reactions. European Journal of Organic Chemistry, 2019(12), 2289-2296.

Bloemendal, V. R., Moons, S. J., Heming, J. J., Chayoua, M., Niesink, O., van Hest, J. C., Hest & Rutjes, F. P. (2019). Chemoenzymatic Synthesis of Sialic Acid Derivatives Using Immobilized N‐Acetylneuraminate Lyase in a Continuous Flow Reactor. Advanced Synthesis & Catalysis, 2019(361), 2443-2447


Scientific publications

De Martino, M. T., Abdelmohsen, L. K., Rutjes, F. P., & van Hest, J. C. (2018). Nanoreactors for green catalysis. Beilstein journal of organic chemistry, 14(1), 716-733.

Hiebler, K., Lichtenegger, G. J., Maier, M. C., Park, E. S., Gonzales-Groom, R., Binks, B. P., & Gruber-Woelfler, H. (2018). Heterogeneous Pd catalysts as emulsifiers in Pickering emulsions for integrated multistep synthesis in flow chemistry. Beilstein journal of organic chemistry, 14(1), 648-658.

Tonin, F., & Arends, I. W. (2018). Latest development in the synthesis of ursodeoxycholic acid (UDCA): a critical review. Beilstein journal of organic chemistry, 14(1), 470-483.

Fitzpatrick, D. E., Maujean, T., Evans, A. C., & Ley, S. V. (2018). Across‐the‐World Automated Optimization and Continuous‐Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud‐Based Server. Angewandte Chemie, 130(46), 15348-15352.

Fitzpatrick, D. E., Mutton, R. J., & Ley, S. V. (2018). In-line separation of multicomponent reaction mixtures using a new semi-continuous supercritical fluid chromatography system. Reaction Chemistry & Engineering, 3(5), 799-806.